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Progress in Medicinal Chemistry, Volume 56 1st Edition (hardcover)

Progress in Medicinal Chemistry, Volume 56 1st Edition (hardcover)

Autor:

Editorial:
Elsevier(Estados Unidos)

Año de edición:

ISBN:
9780444639394

Páginas:
174

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Descripción

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators.

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Table of Contents

Chapter One: Enabling Chemistry Technologies and Parallel Synthesis—Accelerators of Drug Discovery Programmes
 
Abstract
1 Introduction
2 The Evolution of Flow-Based Approaches to Synthesis
3 Use of High-Temperature Chemistries
4 Use of Photochemical and Electrochemical Reactions
5 Use of Hazardous Gases (e.g. Diazomethane) in Flow
6 Library Design Tools and Processes
7 Use of Flow Chemistry for Library Synthesis
8 Summary and Future Perspectives
Acknowledgements
Chapter Two: Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease
 
Abstract
1 Introduction
2 LRRK2 Biology
3 Structural Biology of LRRK2
4 Overview of Selective Inhibitors of LRRK2
5 Conclusion
Chapter Three: Recent Progress in the Discovery and Development of TRPA1 Modulators
 
Abstract
1 TRPA1: An Introduction
2 Validation as a Target for Drug Discovery
3 Medicinal Chemistry and Clinical Status of TRPA1 Modulators
4 Recent Structural Insights
5 Conclusions and Outlook
Chapter Four: Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)
 
Abstract
1 Introduction
2 Small Molecule IRAK4 Inhibitor Discovery
3 Summary of Clinical Status
4 Conclusion
Description
Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators.
 
Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.
 

Key Features

Extended, timely reviews of topics in medicinal chemistry
Contains targets and technologies relevant to the discovery of tomorrow’s drugs
Presents analyses of successful drug discovery programs

Readership

Everyone interested in the strategy and practice of the preclinical phases of the creation of new medicines. Those wishing to understand the drivers of drug design or expand their knowledge of therapeutic target classes

Catalogado en

Ciencia - Química / Farmacia - Pharmacy

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