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Validamycin and Its Derivatives 1st Edition.

Validamycin and Its Derivatives 1st Edition.

Autor:

Editorial:
Elsevier(Estados Unidos)

Año de edición:

ISBN:
9780081009994

Páginas:
340

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Descripción

Discovery, Chemical Synthesis, and Biological Activity

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Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.
 
Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. View more >


Key Features

Offers complete coverage of validamycin chemistry from a highly experienced team of authors
Encourages the discovery of further novel drugs based on validamycin derivatives
Presents an interesting model for establishing new pharmaceutical leads from agricultural sources
Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines
Readership
Medicinal chemists and pharmaceutical scientists, particularly those working on the development of novel antibiotics and antidiabetic drugs; biomedical scientists; agricultural chemists; academic researchers and postgraduates studying medicinal chemistry
 
Table of Contents
Chapter 1. An Introduction to Validamycins and Their Derivatives
 
Abstract
1.1 Importance of Antibiotics
1.2 Agricultural Antibiotics for Plant Pathogens
1.3 Validamycins: Magic Agricultural Antibiotics
1.4 Aims of the Work
References
Chapter 2. Production of Validamycins
 
Abstract
2.1 Discovery of Validamycins
2.2 Microbes for Producing Validamycins
2.3 Production and Isolation of Validamycins and Related Natural Compounds
2.4 Structures, Characterization, and Properties of Validamycins and Related Natural Compounds
2.5 Biosynthesis of Validamycins
2.6 Detection of Validamycin A
2.7 Microbial Degradation of Validamycin A
2.8 Cloning, Expression, and Deficiency of Genes in the Validamycin Biosynthesis and Their Applications
2.9 Fermentation Process for Production of Validamycins
References
Chapter 3. Bioactivities of Validamycins and Related Natural Compounds
 
Abstract
3.1 Antifungal Activities
3.2 Enzyme Inhibitory Activities
3.3 Insecticidal Activity of Validoxylamine A and Related Compounds
References
Chapter 4. Chemical Synthesis of Validamycin and Related Natural Compounds
 
Abstract
4.1 Synthesis of Valienamine
4.2 Synthesis of epi-Valienamine
4.3 Synthesis of Valiolamine
4.4 Synthesis of Validamine
4.5 Synthesis of Hydroxyvalidamine
4.6 Synthesis of Validoxylamines
4.7 Synthesis of Validamycins
References
Chapter 5. Voglibose: An Important Drug for Type 2 Diabetes
 
Abstract
5.1 Chemical Structures of Various Pseudoaminosugar Glucosidase Inhibitors
5.2 α-D-Glucosidase Inhibitory Activity N-Substituted Valiolamine Derivatives and Related Compounds
5.3 Physicochemical Properties of Voglibose and Drug Summary
5.4 Preparation of Voglibose
5.5 Pharmacology, Pharmacokinetics, and Pharmacodynamics
5.6 Clinical Efficacy
5.7 Safety and Tolerability
5.8 Comparison With Other Drugs of Acarbose and Miglitol
5.9 Market and Development
References
Chapter 6. N-Octyl-β-Valienamine and N-Octyl-4-epi-β-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy
 
Abstract
6.1 Chaperone Therapy
6.2 N-Octyl-β-valienamine for Chaperone Therapy of Gaucher Disease
6.3 N-Octyl-4-epi-β-valienamine for Chaperone Therapy of GM1-Gangliosidosis
6.4 Future Perspectives and Conclusion
References
Chapter 7. Prospects and Concluding Remarks
 
Abstract

Catalogado en

Ciencia - Química / Farmacia - Pharmacy

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